SUSTAINABLE CHEMISTRY IN FLOW

 

A definition

"Sustainable chemistry is a scientific concept that seeks to improve the efficiency with which natural resources are used to meet human needs for chemical products and services. Sustainable chemistry encompasses the design, manufacture and use of efficient, effective, safe and more environmentally benign chemical products and processes."

Organisation for economic co-operation and development (accessed 2020-03-24)

 

Principle 6 & 9

"Energy requirements of chemical processes should be recognized for their environmental and economic impacts and should be minimized. If possible, synthetic methods should be conducted at ambient temperature and pressure.”

"Catalytic reagents (as selective as possible) are superior to stoichometry reagents."

The green chemisTREE: 20 years after taking root with the 12 principles.
Green Chem., 2018, 20, 1929-1961

 

Trend to photochemical-assisted biocatalysis

"In medicinal chemistry research, many disciplines have joint forces to design and produce libraries of chemical compounds which are essential for the development of drug candidates with very specific mode of action against various diseases. Often, special functional groups in the molecule like fluorine-containing moieties or stereochemical centres define such mode of action and lead to, e.g., improved pharmacokinetics or transport into or inside cells. Especially the stereochemical conformation of a drug molecule can have massive impact on the mode of action. In this case, either complex synthesis routes with expensive chiral catalysts are necessary and/or a cost-intensive purification must be done afterwards. Hence, the request for more straightforward routes to access such chiral molecules resulted in the adaptation of biological catalysts, enzymes, for the stereo-controlled synthesis of complex molecules. In conjunction with the development of visible light photocatalysis and the plethora of available metal-based photocatalysts or purely organic dyes, photochemical-assisted biocatalysis is becoming a hot spot of current research in synthetic (bio)organic chemistry. Visible light as low energy carrier does not interrupt the enzyme activity due to light absorption by aromatic amino acid moieties of the enzyme as it is the case for UV light. Hence, photocatalysis and biocatalysis are energy-independent from each other and allow a very powerful synergistic use of both modes of catalysis."

in Flow chemistry in drug discovery; Eds: J. Alcázar, A. de la Hoz Ayuso, Á. Díaz Ortiz; Springer, Berlin, Heidelberg, 2021

 

Current projects

Ammonpaktor
Hydrogen gas production by photochemcial decomposition of ammonia (2021-2022)

Illuminate
Photochemical-assisted biocatalysis for the continuous-flow synthesis of fine chemicals (2021-2024)

 

Research & Development for sustainable chemistry in flow

Flow chemistry - Access to intensified continuous syntheses

Catalysis - Increasing the conversion and selectivity of chemical reactions

Flow photochemistry - Light as energy source for selective chemical reactions

Electrochemical synthesis - An efficient and environment-friendly process

Sustainable drug synthesis - From batch to flow processing

Reactive intermediates - In situ production of Grignard reagents with continouos process control